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Загальна кількість знайдених документів : 19
Представлено документи з 1 до 19
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Domina E. A. Destabilization of human cell genome under the combined effect of radiation and ascorbic acid [Електронний ресурс] / E. A. Domina, O. P. Pylypchuk, V. M. Mikhailenko // Experimental oncology. - 2014. - Vol. 36, № 4. - С. 236-240. - Режим доступу: http://nbuv.gov.ua/UJRN/EOL_2014_36_4_6 The aim of this study was to investigate peculiarities of ascorbic acid effect on radiation-induced chromosomal aberrations frequency and range in the cultured peripheral blood lymphocytes (PBL) of healthy donors and cancer patients depending on doses of radiation and drug, as well as cells radiosensitivity (in vitro). Methods: test system of human PBL, metaphase analysis of chromosomal aberrations. Ceils were cultivated according to the standard procedures with some modifications. PBL culture was exposed to x-ray radiation in G0- and G2-phases of cell cycle. Immediately after the irradiation the culture was treated with ascorbic acid in concentrations of 20,0 - 80,0 mu g/ml of blood. Cell culture irradiation in low dose (0,3 Gy) and treatment with ascorbic acid in therapeutic concentration (20,0 mu g/ml of blood) resulted in radioprotective effect, decreasing overall chromosome aberrations frequency as opposed to radiation effects. It has been established that post-irradiation effect of ascorbic add upon the PBL culture in concentrations of 40,0 and 80,0 mu g/ml, which exceeding therapeutic concentration value 2 and 4 times correspondingly, increased overall chromosome aberrations frequency 1,4 times compared with irradiation effect in a low dose (0,3 Gy). This bears evidence of ascorbic acid comuta-genic activity in the range of concentrations exceeding therapeutic values. The peak of mitotic activity inhibition was observed at 2,0 Gy irradiation dose. Addition ascorbic acid in therapeutic concentration increased radiation effect this number approx 2 times (exceeding even intact control value). Compared with G0-phase, co-mutagenic effect of ascorbic add in G2-phase appears earlier, starting with dose of 1,0 Gy. In the blood lymphocytes of cancer patients, the level of genetic damage was increased 1,7 times after combined treatment with low dose irradiation and ascorbic acid in comparison with irradiation alone which suggest the co-mutagenic instead of radioprotective effect of ascorbic acid. Conclusions: genome destabilization enhancement of irradiated in vitro human somatic cels under ascorbic acid effect is due to its co-mutagenic properties. The formation of comutagenic effects of ascorbic acid depend on its concentration, irradiation dose and tbc efficiency of repair processes. Co-mutagenes may pose high carcinogenic hazard at low (above background) radiation levels.
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Pylypchuk O. Work in the interests of rail transport: the second Minister of Railway Transport of the Russian Empire – Volodymyr O. Bobrynskyi (1869-1871) [Електронний ресурс] / O. Pylypchuk, O. Strelko // Історія науки і техніки. - 2019. - Т. 9, Вип. 1. - С. 19-32. - Режим доступу: http://nbuv.gov.ua/UJRN/ictnt_2019_9_1_4
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Pylypchuk O. The rights of juveniles in civil procedure (the 2nd half of the ХІХ century) [Електронний ресурс] / O. Pylypchuk // Історія науки і техніки. - 2019. - Т. 9, Вип. 1. - С. 120-129. - Режим доступу: http://nbuv.gov.ua/UJRN/ictnt_2019_9_1_12
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Pylypchuk O. Legislative activities of the Kyiv Law society in the field of railway transport [Електронний ресурс] / O. Pylypchuk // Історія науки і техніки. - 2019. - Т. 9, Вип. 2. - С. 225-232. - Режим доступу: http://nbuv.gov.ua/UJRN/ictnt_2019_9_2_10
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Vainberg V. V. Low temperature charge transport in arrays of single-walled carbon nanotube bundles with radiation induced defects [Електронний ресурс] / V. V. Vainberg, V. N. Poroshin, O. S. Pylypchuk, N. A. Tripachko, I. I. Yaskovets // Semiconductor physics, quantum electronics & optoelectronics. - 2019. - Vol. 22, № 4. - С. 418-423. - Режим доступу: http://nbuv.gov.ua/UJRN/MSMW_2019_22_4_10 Electric transport properties and magnetoresistance (MR) of the array of metallic single-wall carbon nanotube bundles irradiated by the electron flux with the energy close to 1 MeV or Co<^>60 gamma quanta have been investigated within the temperature range T = 1,8 - 200 K and in the magnetic fields up to 5 T. The power-law behavior of the conduction vs temperature was observed within the range 50 to 200 K, which is typical for conduction of quasi-one-dimensional systems in the model of the electron gas as the Luttinger liquid. The change in power exponent <$E alpha> with the radiation dose and its deviation as compared to <$E alpha> for the non-irradiated samples is related with changing the number of conduction channels in the bundles as a consequence of the radiation defects appearance. At the temperatures below 50 K, the Mott three-dimensional hopping conduction is realized. Using the measured dependence of conduction on the temperature and electric field, the density of electron states in the vicinity of the Fermi level, which participate in the hopping charge transport, and the localization length of charge carriers in these states have been determined. These parameters determining the hopping mechanism of the charge transport are noted to depend on the radiation dose. The magnetoresistance in the Mott-type hopping conduction region was negative in the whole range of magnetic fields, while at the large fields an upturn to the positive change was observed. The mechanisms both of the negative and positive MR components are discussed.Electric transport properties and magnetoresistance (MR) of the array of metallic single-wall carbon nanotube bundles irradiated by the electron flux with the energy close to 1 MeV or Co<^>60 gamma quanta have been investigated within the temperature range T = 1,8 - 200 K and in the magnetic fields up to 5 T. The power-law behavior of the conduction vs temperature was observed within the range 50 to 200 K, which is typical for conduction of quasi-one-dimensional systems in the model of the electron gas as the Luttinger liquid. The change in power exponent <$E alpha> with the radiation dose and its deviation as compared to <$E alpha> for the non-irradiated samples is related with changing the number of conduction channels in the bundles as a consequence of the radiation defects appearance. At the temperatures below 50 K, the Mott three-dimensional hopping conduction is realized. Using the measured dependence of conduction on the temperature and electric field, the density of electron states in the vicinity of the Fermi level, which participate in the hopping charge transport, and the localization length of charge carriers in these states have been determined. These parameters determining the hopping mechanism of the charge transport are noted to depend on the radiation dose. The magnetoresistance in the Mott-type hopping conduction region was negative in the whole range of magnetic fields, while at the large fields an upturn to the positive change was observed. The mechanisms both of the negative and positive MR components are discussed.
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Pylypchuk O. Energy efficiency aspects of coloristic opportunataes of interior space with inclusion of artistic-decorative forms [Електронний ресурс] / O. Pylypchuk // Технічна естетика і дизайн. - 2019. - Вип. 16. - С. 58-71. - Режим доступу: http://nbuv.gov.ua/UJRN/texnect_2019_16_8
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Pylypchuk O. Ya. Ecological activity on a raiway transport: her essense, actual tasks, place and role in the national ecological policy of Ukraine [Електронний ресурс] / O. Ya. Pylypchuk // Вісник Східноукраїнського національного університету імені Володимира Даля. - 2020. - № 3. - С. 48-53. - Режим доступу: http://nbuv.gov.ua/UJRN/VSUNU_2020_3_12
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Pylypchuk O. Preface [Електронний ресурс] / O. Pylypchuk, О. Strelko, Y. Berdnychenko // Історія науки і техніки. - 2020. - Т. 10, Вип. 2. - С. 160-162. - Режим доступу: http://nbuv.gov.ua/UJRN/ictnt_2020_10_2_3
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Pylypchuk O. Preface [Електронний ресурс] / O. Pylypchuk, О. Strelko, Y. Berdnychenko // Історія науки і техніки. - 2021. - Т. 11, Вип. 1. - С. 7-9. - Режим доступу: http://nbuv.gov.ua/UJRN/ictnt_2021_11_1_3
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Strelko O. Analysis of Klavdii Semyonovich Nemeshaev’s activities as the Minister of Railways of the Russian Empire [Електронний ресурс] / O. Strelko, O. Pylypchuk // Історія науки і техніки. - 2021. - Т. 11, Вип. 1. - С. 233-261. - Режим доступу: http://nbuv.gov.ua/UJRN/ictnt_2021_11_1_16
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Pylypchuk O. Preface [Електронний ресурс] / O. Pylypchuk, О. Strelko, Y. Berdnychenko // Історія науки і техніки. - 2021. - Т. 11, Вип. 2. - С. 271-273. - Режим доступу: http://nbuv.gov.ua/UJRN/ictnt_2021_11_2_3
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Strelko O. Characteristics of unpaved roads in the late 18th century – early 19th century, and the design of the first wooden trackway as a forerunner to the Bukovyna railways [Електронний ресурс] / O. Strelko, O. Pylypchuk // Історія науки і техніки. - 2021. - Т. 11, Вип. 2. - С. 437-452. - Режим доступу: http://nbuv.gov.ua/UJRN/ictnt_2021_11_2_12
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Pylypchuk O. Preface [Електронний ресурс] / O. Pylypchuk, О. Strelko, Y. Berdnychenko // Історія науки і техніки. - 2022. - Т. 12, Вип. 1. - С. 7-10. - Режим доступу: http://nbuv.gov.ua/UJRN/ictnt_2022_12_1_3
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Strelko O. Study of development of regional railway system in Bukovyna [Електронний ресурс] / O. Strelko, O. Pylypchuk, O. Pylypchuk // Історія науки і техніки. - 2022. - Т. 12, Вип. 1. - С. 133-149. - Режим доступу: http://nbuv.gov.ua/UJRN/ictnt_2022_12_1_10
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Pylypchuk O. Preface [Електронний ресурс] / O. Pylypchuk, О. Strelko, Y. Berdnychenko // Історія науки і техніки. - 2022. - Т. 12, Вип. 2. - С. 194-196. - Режим доступу: http://nbuv.gov.ua/UJRN/ictnt_2022_12_2_3
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Pylypchuk O. Preface [Електронний ресурс] / O. Pylypchuk, О. Strelko, Y. Berdnychenko // Історія науки і техніки. - 2023. - Т. 13, Вип. 1. - С. 7-9. - Режим доступу: http://nbuv.gov.ua/UJRN/ictnt_2023_13_1_3
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Pylypchuk O. Review of the monograph: I. O. Demuz. Intellectual biography of Petro Yanuarovych Stebnytskyi (1862‒1923) – public figure, book publisher, publicist: monograph. Pereyaslav (Kyiv region): Dombrovska Ya. M., 2022. 356 pp. [Електронний ресурс] / O. Pylypchuk // Історія науки і техніки. - 2023. - Т. 13, Вип. 1. - С. 223-226. - Режим доступу: http://nbuv.gov.ua/UJRN/ictnt_2023_13_1_14
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Pylypchuk O. Preface [Електронний ресурс] / O. Pylypchuk, О. Strelko, Y. Berdnychenko // Історія науки і техніки. - 2023. - Т. 13, Вип. 2. - С. 240-242. - Режим доступу: http://nbuv.gov.ua/UJRN/ictnt_2023_13_2_3
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Ustymenko I. Study on the use of food emulsion and xanthan gum in the composition of yogurt with blended oil [Електронний ресурс] / I. Ustymenko, N. Slobodyanyuk, O. Savchenko, H. Tolok, O. Pylypchuk // Здоров'я людини і нації. - 2023. - № 1. - С. 49-62. - Режим доступу: http://nbuv.gov.ua/UJRN/hnh_2023_1_6
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